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Konstantinos Krampis Konstantinos Krampis,
Associate Professor of Biological Sciences


  • PI, Bioinformatics Core Informatics Infrastructures Laboratory (BCIL)
  • Director of Bioinformatics, Center for Translational and Basic Research (CTBR)
  • Faculty at the Institute for Computational Biomedicine (ICB), Weill Cornell Medical College

Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Office:Rm. 467F Belfer Research Building
413 East 69th Street New York, NY 10021
Phone: (212) 396-6930

Lab Web Site:


Research Web Site:


Education:


List of Current Manuscripts:


Academic Appointments:


Research Areas:

  1. High-throughput bioinformatics infrastructures for cluster and cloud computing platforms.
    1. Scalability of data analysis pipelines using distributed computing: Kubernetes, NextFlow, Docker Swarm.
    2. Cross-platform bioinformatics through Docker virtualization in clinical and basic research.
    3. Visualization of genomic data on cloud databases using HTML5 / D3.js and in-browser computing.
  2. Bioinformatics for Next Generation Sequencing (NGS) clinical and personal genomics.
    1. NGS data pipelines for QC, RNA-seq, Hi-C, metagenomics, variant discovery, genome assembly.
    2. Integrative analysis of variation, expression, chromatin and epigenetic data from TCGA, Encode, 4DN.
    3. Scalable, accessible pipelines for metagenomics, clinical samples and personal genomics on Galaxy.
  3. Interdisciplinary research and novel applications of genomic sequencing and bioinformatics.
    1. Portable NGS and bioinformatics with Nanopore Minion and Intel Next Units of Computing (NUC).
    2. Touch-enabled, mobile computing interfaces for personal genomics and clinical NGS data visualization.
    3. Metabarcoding for conservation and biodiversity monitoring using environmental DNA (eDNA).
  4. Algorithmic Information Theory, Computability, and Biologically-Inspired Computing.
    1. Emergence, complexity, information content and compressibility of epigenetic networks.
    2. Integrating DNA computing with NGS sequencing for reading molecolar output with high I/O.
    3. Computability and decidability of biologically-inspired and DNA computing models.

Grants:

  1. Principal Investigator.
    2017 - 2018 CUNY Advanced Science Research Center (ASRC) Seed Award Program. Project Title: "Next Generation Sequencing for environmental DNA monitoring: understanding global biodiversity through bioinformatics”. Amount: $10,000
    2016 - 2017 CUNY Center for Translational and Basic Research Pilot Award. Project Title: "Democratizing access to bioinformatics computing for health disparities research”. Amount: $78,000
    2015 - 2016 National Institutes of Health. Project Title: “Expanding Infrastructure and Services of CUNY-CTBR Bioinformatics and Genomics Core”. Amount: $123,832
    2015 - 2017 Weill Cornell Medical College, Clinical and Translational Science Center Pilot Award. Project Title: "Cross-platform, scalable Science as a Service (SciaaS) infrastructures for NGS data analysis”. Amount: $110,660
    2014 - 2016 City University of New York. “Faculty startup award”. Amount $100,000
    2014 - 2015 National Institutes of Health. “Development of a Bioinformatics Core and Sequencing Facility at Hunter College for Minority Health Disparities Research”. Amount: $485,000
    2011 - 2014 National Institutes of Health. "Large-Scale Prokaryotic and Viral Next-Gen Sequencing Data Pipelines Using Cloud Computing”. Amount: $661,217
  2. Co-Principal Investigator.
    2017 - 2018 National Institutes of Health. Project Title: “Mechanisms of regulation of progenitor proliferation and transformation” (ASRC Neuroscience sub-contract). Amount: $10,920
    2014 - 2015 National Science Foundation. Project Title: “Development of the next-generation Arabidopsis Informatics Portal”. Amount: $2,434,910

Honors and Awards:

  2018 Proposal Development / Faculty Research Award, City University of New York
  2017 President’s Travel Award, Hunter College, City University of New York
  2014 Entrepreneurship Lab NYC Selected Participant and Top 20 (300+ entries) Business Plan
  2011 Bioinformatics Open Source Conference – Best Audience Voted Presentation Award
  2008 Virginia Tech Graduate Association Executive Board Elected Member
  2008 Virginia Tech Outstanding Interdisciplinary Doctoral Student Award
  2008 Horace E. Alphin Doctoral Tuition Scholarship
  2007 Virginia Tech Graduate Student Assembly Research Award
  2004-2006 James and Ina Mae Doctoral Tuition Scholarship

Teaching and Mentoring:

  1. Courses Developed and Taught.
    2014 - 2016 “Programming for Computational Biology”. Computer coding for biologists, covering basic data types, program flow control, functions, regular expressions, working with NGS files, and object-oriented programming.
    2015 - Present “Computational Molecular Biology”. Sequence pattern matching, alignment, read mapping, variant calling, genome assembly, and gene prediction algorithms, in addition to data structures for efficient NGS data storage, taught based on the latest literature.
    2015 - Present “Next-Generation Sequencing Data Analysis”. Concepts of sequencing technology, data formats and bioinformatics tools, implementation of data pipelines on the command line or online Galaxy interface for RNA-seq, ChIP-seq, and metagenomics.
  2. Workshops Developed and Taught.
    2018 “A Plug and Play, on-Premises Bioinformatics Cloud, Providing Seamless, Single-Step Execution of NGS Pipelines”, Plant and Animal Genome International Conference, San Diego, CA.
    2017 “Deploying Large-Scale Bioinformatics Workflows with Kubernetes on a Google Cloud Computer Cluster”, Bioinformatics Open Source Conference & Hackathon, Prague, Czech Republic.
    2016 “NGS Sample Processing and Data Analysis through the CTBR Facility and Bioinformatics Computer Cluster”, workshop for CUNY and Weill Cornell Medical College faculty and students, New York, NY.
    2015 “Scalable, Intuitive Genomic Sequencing Data Analysis with Galaxy and Cloud BioLinux”, New York City College of Technology, New York, NY.
    2014 “Cloud BioLinux: Pre-Configured and On-Demand Virtual Machines for NGS Data Analysis”, 27th CTBR Symposium: Bioinformatics Applications in Health Disparities, New York, NY.
    2013 “Genomic Sequencing Data Analysis using Cloud Computing and the Amazon EC2 platform”, NYU Center for Health Informatics and Bioinformatics, New York, NY.
    2012 “South Africa National Research Network Workshop - Cloud BioLinux for High Performance Data Analysis”, Center of High Performance Computing, Johannesburg, South Africa.
    2012 “Empowering Genomics in South Africa Workshop - Cloud Computing Solutions for Genome Sequence Data Analysis”, University of Limpopo, Polokwane, South Africa.
    2011 “Cloud BioLinux for Bioinformatics Open Source Applications”, International Society for Computational Biology Conference, Vienna, Austria.
    2011 “Biologically Inspired Approaches to Resilience”, Institute of Human and Machine Cognition, Ocala, FL.
    2010 “From monolithic to distributed bioinformatics on the cloud”, Amazon Web Services, Seattle, WA.
  3. Graduate Students Mentored.
    2015 - Present Jason Mighty, Ph.D. Candidate, Biological Sciences Dept. at Lehman College & CUNY Graduate Center, Thesis topic: "Characterization of small RNAs Toward Development of Novel Biomarkers for Retinal Disease".
    2015 - Present Allen Pan, Ph.D. Candidate, Biological Sciences Dept. at Hunter College & CUNY Graduate Center, Thesis topic: "Transcriptomics of Neuroprotective Mechanism of Epigallocatechin-3-gallate on Methamphetamine-induced neurotoxicity".
    2014 - Present Juliette Gorson, Ph.D. Candidate, Chemistry Dept. at Hunter College & CUNY Graduate Center, Thesis topic: "Connecting venom gene expression, function and species diversity in predatory marine snails of the Terebridae".
    2014 - 2017 Samuel Hosmer, Ph.D. Candidate, Mathematics Dept. at Hunter College & CUNY Graduate Center, Spring 2015 internship on "Implementation of cloud computing based data analysis pipeline for CHIP-seq genomic sequencing data".
    2010 - 2012 Priti Kumari, M.Sc. Bionformatics, Biochemistry Dept. at George Washington University, Thesis topic: "Parallel and Cloud Computing Based Genome Assembly Using Bidirected String Graphs".
    2010 - 2012 Vivek Sarangi, M.Sc. Bionformatics, Biochemistry Dept. at George Washington University, Thesis topic: "Development and Evaluation of Cloud Computing Infrastructures for Next-Gen Sequencing Data analysis".
  4. Undergraduate Students and Interns Mentored.
    2014 - Present Bioinformatics Internship in Bioinformatics Core Infrastructures Lab. Undergraduate interns join my research group for 3 to 6 months and participate in various research projects.
    2016 Science Research Mentor at Urban Barcoding Project (UBRP) by Cold Spring Harbor Laboratory, NY. Mentored high-school students 1-2 hours weekly during the course of 9 months; the students worked on a metagenomics study to assess marine biodiversity.
    2015 Mentor, Science Research Mentoring Program (SRMP), American Museum of Natural History, NY. Mentored high-school students 4 hours weekly during the course of 9 months, who worked NGS bioinformatics pipelines and data visualization using the Galaxy server.
    2014 Summer Bioinformatics Workshop organized by Hunter Science High-School in New York City. Taught high-school students 3 hours weekly during the course of 9 months on bioinformatics programming and analysis of genomic sequencing datasets.

Institutional Committee and Scientific Service:

  1. Graduate and undergraduate education committees.
    2016 - Present Co-Chair, Ethics and Integrity Committee at the City University of New York. Organized a faculty working group to perform research and write a report as part the application for accreditation of CUNY by the Middle States Committee in Fall 2019.
    2015 - Present Bioinformatics M.Sc. Program at CUNY. Designed and wrote the program proposal, assembling a group of faculty and curriculum using existing and newly designed courses.
    2015 - 2016 CUNY Data Science Committee. Contributed towards designing Data Science courses and developed two training grant proposals (NSF, NIH) to fund a Bioinformatics Data Science Ph.D. program.
    2014 - 2015 CUNY Quantitative Biology Program Faculty. Worked towards planning new bioinformatics syllabi and course modules, contributing to undergraduate (e.g., biology, computer science) and graduate (e.g., bioinformatics) curricula.
  2. Editorial Positions, Boards and Peer-Review Service. .
    Oxford Bioinformatics; BMC Bioinformatics; BMC Research Notes; Nature Methods; Nature Scientific Reports; PLoS ONE; In Silico Biology; Future Generation Computer Systems; BioMed Research International; British Journal of Mathematics and Computer Science; Journal of Bioinformatics & Computational Biology; Genome Technology; GigaScience; F1000 Research.
  3. Memberships in Professional Societies. .
    Since 2013 Illumina Basespace Developers Community
    Since 2009 Open Bioinformatics Foundation
    Since 2009 Bioinformatics Open Source Conference
    Since 2009 Galaxy Developers Community
    Since 2006 Bioinformatics IT World
    Since 2003 International Society for Computational Biology

Extramural Invited Presentations:

  1. Graduate and undergraduate education committees.
    2018 High-Throughput Sequencing Computational Standards for Regulatory Sciences, Washington, DC .
    2017 Dept. of Public Health Sciences, Penn State College of Medicine, Hershey, PA
    2017 Dept. of Human Genetics, University of Pittsburgh, Pittsburgh, PA.
    2017 Intelligent Systems for Molecular Biology (ISMB), Prague, Czech Republic.
    2017 High-Throughput Sequencing Computational Standards for Regulatory Sciences, Washington, DC .
    2017 Dept. of Computational Medicine, University of Michigan, Ann Arbor, MI
    2016 Bioinformatics Ph.D. Program Guest Lecture, NYU Langonne Medical Center, New York, NY
    2015 Global Health Informatics Conference, University of South Florida, Tampa, FL
    2015 Biological Sciences Research Seminar, Lehman College, New York, NY
    2015 Illumina Basespace Conference, Broad Institute, Cambridge, MA
    2014 Galaxy Developer’s Conference, John Hopkins University, Baltimore, MD
    2014 CTBR 27th Symposium: Bioinformatics & Medical Applications, New York, NY
    2012 Cloud Computing Bioinformatics Symposium, Center Genomic Regulation, Spain
    2012 Translational Bioinformatics On The Cloud, J&J Inc., New Brunswick, NJ
    2012 NIH-NIAID Bioinformatics Symposium, Bethesda, MD
    2011 Genomics Standards Consortium, European Bioinformatics Institute, Hinxton, UK

Bibliography - Published Manuscripts


Bibliography - Monographs

  1. .Krampis K. “Cloud Computing for Bioinformatics: Next-Gen Sequencing and Large-Scale Data Analytics” Monograph to be published in 2019, contract signed with Cambridge University Press, Cambridge, UK.

Bibliography - Book Chapters

  1. Krampis K., Efstratios E. and Brown S.T. (2015, 2017). “Cloud-Based Next-Generation Sequencing Informatics”. Book Chapter in Next-Generation DNA Sequencing Informatics (pp. 361-370), First & Second Edition. Cold Spring Harbor Press, NY.
  2. Rusch D.B., Miller J., Krampis K., Tovchigrechko A., Sutton G., Yooseph S. and Nelson K.E. (2014). “Bioinformatics for Genomes and Metagenomes in Ecology Studies”. Book Chapter in Infectious Microecology (pp. 203-226). Springer GmbH & Co, Berlin, Germany.
  3. Goll J.B, Szpakowski S., Krampis K. and Nelson K.E. (2014). “Next-generation sequencing, metagenomes, and the human microbiome”. Book chapter in Bioinformatics and Data Analysis in Microbiology (Chpt. 7). Caister Academic Press, Norfolk, U.K.
  4. Nelson K.E., Madupu R., Szpakowski S., Goll J.B., Krampis K. and Methe B.A. (2014). “Next-generation sequencing, metagenomes, and the human microbiome”. Book chapter in Next-generation Sequencing: Current Technologies and Applications (pp. 141-155). Caister Academic Press, Norfolk, U.K.
  5. Quirino B.F., Barreto C.C., Pappas G.J., Zengler K., Krampis K. and Krüger R.H. (2013). “Genomes and Post-Genome Technology” Book Chapter in Prokaryotes (pp. 329-344). Springer GmbH & Co., Berlin, Germany.
  6. Madupu R., Rogers Yu-H., Rusch D., Miller J., Krampis K. and Nelson K.E. (2012). “Microbiomes”. Book Chapter in Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH Verlag GmbH & Co., Weinheim, Germany.
  7. Miller J., Rusch D., Krampis K., Tovichgrechko A., Sutton G., Yooseph S. and Nelson K.E. (2012). “Bioinformatics for Genomes and Metagenomes in Microbial Ecology Studies”. Book Chapter in Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH Verlag GmbH & Co., Weinheim, Germany.
  8. Tyler B.M., Jiang R.H., Zhou L., Tripathy S., Dou D., Torto-Alalibo T., Li H., Mao Y., Liu B., Vega-Sanchez M., Mideros S.X., Hanlon R., Smith B.M., Krampis K., Ye K., Martin S.S., Dorrance A.E., Hoeschele I. and Sagahi Maroof M.A. (2008). “Functional genomics and bioinformatics of the Phytophthora sojae soybean interaction”. Book Chapter in Genomics of Disease (pp. 67-78). Springer GmbH & Co, NY.

Bibliography - Other Media:

  2014 - Present Video tutorials on published bioinformatics software: http://tinyurl.com/BCIL-channel
  2014 - Present Bioinformatics Core Infrastructures Laboratory (BCIL), repository for active open source bioinformatics software development projects: https://github.com/BCIL
  2014 - Present Docker containers with pre-configured bioinformatics data pipelines: https://hub.docker.com/u/bcil
  2012 - Present Cloud BioLinux Project and the first Bioinformatics Virtual Machine: http://cloudbiolinux.org https://en.wikipedia.org/wiki/CloudBioLinux

Last Updated ( Wednesday, 17 January 2018 18:00 )